COMPOSITION :
Covaryl - 2
Each enteric-coated tablet contains
Molsidomin.......................2mg

Covaryl - 4
Each enteric-coated tablet contains
Molsidomin.......................4mg
 

Molsidomine, an effective long-acting anti-anginal drug:
Molsidomine is an orally active, long acting, NO releasing vasodilator which requires hepatic metabolism for activity but which does not cause pharmacological tolerance. Molsidomine is a NO-releasing prodrug. Liver esterases convert molsidomine to the active metabolite, SIN-1 (half-life in plasma is 1-2 hours), which then releases NO. Used: in severe cases of angina pectoris.

Abstract :
Molsidomine was compared with propranolol for anti-anginal efficacy in a double-blind, cross-over, fixed-dose clinical trial, involving 39 patients with moderate, stable angina pectoris, and objective evidence of coronary sclerosis. The incidence of anginal attacks under molsidomine did not differ statistically from that under propranolol. However, propranolol was more effective in reducing the nitroglycerin requirement at the doses used. Ergometry showed that both drugs increased exercise tolerance to a comparable extent. However the rate pressure product during exertion indicates that these drugs achieve this result via different paths, molsidomine having a nitrate-like effect. Unwanted effects during the four week treatment periods were minor and generally tolerable.

Molsidomine is an effective long-acting anti-anginal agent with nitrate-like effects and should be a useful addition to the drugs already in use.

Pharmaceutical active ingredients:
Molsidomine

Forms:
Tablet; Oral; Molsidomine 2 mg
Tablet; Oral; Molsidomine 4 mg
Injectable; Injection; Molsidomine 2 mg / ml

Destination / Category:

Human
Indications and usages:

ATC
ICD-10
DOSAGE AND ADMINISTRATION
Prevention of ischaemic events
The recommended dose is one tablet once daily.

Acute coronary syndrome
Loading dose: Four tablets.
Maintenance: One tablet daily

PACKAGING INFORMATION :
COVARYL -2: Blister of 10 tablets
COVARYL -4: Blister of 10 tablets
 

Note: This product information is intended only for residents of the India. Taj Pharmaceuticals Limited,  medicines help to treat and prevent a range of conditions—from the most common to the most challenging—for people around the world.

Information for Health Care Professionals

*** Please consult local Prescribing Information for any product before use. This website is an international information resource for healthcare professionals with an interest in disease management. This website is not intended to replace the advice of a qualified healthcare professional. Above brand is a trademark of the Taj group of companies (Taj Pharmaceuticals Limited).

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