Generic Name: DOXAZOSIN AS MESYLATE

Active Ingradiant: DOXAZOSIN AS MESYLATE

DOXAZOSIN AS MESYLATE 1 mg film-coated tablets -Cardiovascular

DOXAZOSIN AS MESYLATE 2 mg film-coated tablets -Cardiovascular

Drug indication:

Doxazosin is one of a group of medicines called alpha-blockers.

doxazosin  tablets are used to treat high blood pressure (hypertension) or the symptoms caused by enlargement of the prostate gland in men.

In patients taking doxazosin to treat high blood pressure (hypertension) doxazosin works by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure.

In patients with enlargement of the prostate gland, doxazosin is taken to treat frequent and/or poor passing of urine. This is common in patients with enlargement of the prostate gland. doxazosin works by relaxing muscle around the bladder exit and prostate gland so urine is passed more easily.

BEFORE YOU TAKE DOXAZOSIN

Do not take the tablets if you:

• have ever had an allergic reaction (hypersensitivity) to doxazosin or any of the other ingredients of doxazosin tablets.

This may have been itching, reddening of the skin or difficulty in breathing.

• are breastfeeding.
• are aged under 16 years of age

Take special care if:

• If you have liver disease tell your doctor before you start taking your tablets.
• If you are pregnant or trying to become pregnant tell your doctor before you start taking your tablets.

If you are undergoing eye surgery because of cataract (cloudiness of the lens) please inform your eye specialist before the operation that you are using or have previously used doxazosin. This is because doxazosin may cause complications during the surgery which can be managed if your specialist is prepared in advance.

When you start to take doxazosin you may experience faintness or dizziness caused by low blood pressure, when getting up from sitting or lying down. If you feel faint or dizzy, you should sit or lie down until you feel better and avoid situations where you might fall or hurt yourself.

Taking other medicines: Some patients who take alpha-blocker therapy for the treatment of high blood pressure or prostate enlargement may experience dizziness or light headedness, which may be caused by low blood pressure upon sitting or standing up quickly. Certain patients have experienced these symptoms when taking drugs for erectile dysfunction (impotence) with alpha-blockers. In order to reduce the likelihood that these symptoms occur, you should be on a regular daily dose of your alpha-blocker before you start drugs for erectile dysfunction.

Please inform your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed.

Driving and using machines:

Take care if you drive or operate machinery. Your tablets may affect your ability to drive or operate machinery safely, particularly when you first start to take them. They may make you feel weak or dizzy. If affected, do not drive or operate machinery and contact your doctor immediately.

Adults and Elderly:

Always take doxazosin exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are unsure.

doxazosin is usually taken once daily. doxazosin may be taken in the morning or the evening.

You can take your tablets before or after food.

You should take your tablets at the same time each day with a small amount of water.

The initial dose of doxazosin is 1mg once daily. Thereafter the dose may be gradually increased (within 1-2 weeks interval) to the usual dose (2mg or 4mg daily).

In some circumstances the dose may be increased to a maximum of 8mg daily if you are being treated for prostate enlargement, or to a maximum of 16mg if you are being treated for high blood pressure.

Children: This medicine is not recommended for children.

If you forget to take tablets:

If you miss a dose just carry on with the next one as normal. Do not take a double dose to make up for the missed one.

If you take more dose than you should:

Too many tablets at once may make you unwell. If several tablets are taken it may be dangerous.

Tell your doctor immediately or go to your nearest hospital casualty department.

POSSIBLE SIDE EFFECTS

Like all medicines, doxazosin can have side effects but not everybody gets them.

Most undesirable effects are usually mild and tend to wear off as treatment goes on. It is important to tell your doctor if any unwanted effect causes you concern, including those which may not be listed below.

Problems doxazosin may cause are:

• allergic reaction, with symptoms such as skin rash, itching, which may be accompanied by shortness of breath, difficulty breathing, swelling of the face, tongue and throat. If any of these symptoms occur, STOP taking doxazosin and seek medical attention immediately.
• The following events have been reported in patients with high blood pressure being treated with doxazosin, but these may be due to the underlying disease rather than the medicine: chest pain, angina, a feeling of increased, decreased or irregular heart beat, palpitations, heart attack or stroke. Contact your doctor immediately if any of these occur.
• low white blood cells (which may result in increasing frequency of infection, sore throat, mouth ulcer, high temperature or stomach upset); low blood platelets [which may result in bruising or bleeding easily, nose bleeds (epistaxis).

If any of these occur contact your doctor.

Other side effects:- generally feeling unwell, weakness, tiredness\sleepiness, swelling of feet or lower legs (oedema), weight gain

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