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Mebrasil® CIV
(brand of mephobarbital tablets, USP)
Mebrasil is a barbiturate.
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Mebrasil is available for oral administration in 32 mg, 50 mg,
and 100 mg tablets.
What is
Mebrasil (mephobarbital)?
Mephobarbital is in a group of drugs called barbiturates
(bar-BIT-chur-ates). Mephobarbital slows the activity of your
brain and nervous system.
Mephobarbital is used as a sedative to treat anxiety, tension,
and apprehension (dreading or feeling uneasy about what you
think may happen). Mephobarbital is also used to treat seizures.
Mephobarbital may also be used for other purposes not listed in
this medication guide.
What is the most important information I should know about
Mebrasil (mephobarbital)?
Do not take this medication if you are allergic to mephobarbital
or to other barbiturates such as amobarbital (Amytal),
butabarbital (Butisol), secobarbital (Seconal), or phenobarbital
(Luminal, Solfoton).
Before taking mephobarbital, tell your doctor if you have liver
or kidney disease, anemia, heart disease, asthma or other
breathing disorder, or a history of depression, mental illness,
suicide attempt, or drug/alcohol addiction.
Do not use mephobarbital without telling your doctor if you are
pregnant. It could cause harm to the unborn baby. Use an
effective form of birth control, and tell your doctor if you
become pregnant during treatment. Mephobarbital can make birth
control pills less effective. Ask your doctor about using a
non-hormone method of birth control (such as a condom,
diaphragm, spermicide) to prevent pregnancy while taking
mephobarbital. Mephobarbital may be habit-forming and should be
used only by the person it was prescribed for. Mephobarbital
should never be shared with another person, especially someone
who has a history of drug abuse or addiction. Keep the
medication in a secure place where others cannot get to it.
What should I discuss with my healthcare provider before
taking Mebrasil (mephobarbital)?
Do not take this medication if you are allergic to mephobarbital
or to other barbiturates such as amobarbital (Amytal),
butabarbital (Butisol), secobarbital (Seconal), or phenobarbital
(Luminal, Solfoton).
If you have any of these other conditions, you may need a
dose adjustment or special tests to safely use mephobarbital:
liver or kidney disease;
anemia (lack of red blood cells);
heart disease;
asthma, chronic obstructive pulmonary disorder (COPD), or other
breathing disorder;
a history of depression, mental illness, or suicide attempt; or
a history of drug or alcohol addiction.
Mephobarbital may be habit-forming and should be used only by
the person it was
 prescribed for. Mephobarbital should never be
shared with another person, especially someone who has a history
of drug abuse or addiction. Keep the medication in a secure
place where others cannot get to it. FDA pregnancy category D.
This medication can cause harm to an unborn baby. It could also
cause addiction or withdrawal symptoms in a newborn if the
mother takes mephobarbital during late pregnancy. Do not use
mephobarbital without your doctor's consent if you are pregnant.
Tell your doctor if you become pregnant during treatment. Use an
effective form of birth control while you are using this
medication. Mephobarbital can make birth control pills less
effective. Ask your doctor about using a non-hormone method of
birth control (such as a condom, diaphragm, spermicide) to
prevent pregnancy while taking mephobarbital. Mephobarbital can
pass into breast milk and may harm a nursing baby. Do not use
this medication without telling your doctor if you are
breast-feeding a baby.
How should I take Mebrasil (mephobarbital)?
Take this medication exactly as prescribed by your doctor. Do
not take it in larger amounts or for longer than recommended.
Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you
get the best results from this medication. Mephobarbital is
sometimes taken several times a day. Follow your doctor's
instructions.
Take this medication with a full glass of water. Do not stop
using mephobarbital without first talking to your doctor, even
if you feel better. You may have increased seizures if you stop
using mephobarbital suddenly. You will need to use less and less
before you stop the medication completely.
If you use this medication long-term, your blood may need to be
tested on a regular basis.
 Your kidney or liver function may
also need to be tested. Do not miss any scheduled appointments.
Store mephobarbital at room temperature away from moisture and
heat. Keep track of how many pills have been used from each new
bottle of this medicine. Mephobarbital is a drug of abuse and
you should be aware if any person in the household is using this
medicine improperly or without a prescription.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost
time for your next dose, wait until then to take the medicine
and skip the missed dose. Do not take extra medicine to make up
the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too
much of this medicine. An overdose of mephobarbital can be
fatal.
Overdose symptoms may include slow or shallow breathing, blurred
vision, extreme drowsiness, decreased body temperature, fast
heart rate, and fainting.
What should I avoid while taking Mebrasil (mephobarbital)?
Mephobarbital can cause side effects that may impair your
thinking or reactions. Be careful if you drive or do anything
that requires you to be awake and alert. Do not drink alcohol
while taking mephobarbital. Alcohol can increase the risk of
fatal overdose with a barbiturate.
Mebrasil (mephobarbital) side effects
Get emergency medical help if you have any of these signs of an
allergic reaction: hives; difficulty breathing; swelling of your
face, lips, tongue, or throat. Call your doctor at once if you
have any of these serious side effects:
confusion, hallucinations;
slow heart rate; or
feeling like you might pass out.
Less serious side effects may include:
dizziness;
memory or thinking problems;
feeling nervous or agitated;
nausea, vomiting; or
headache.
This is not a complete list of side effects and others may
occur. Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Mebrasil (mephobarbital)?
Cold or allergy medicine, narcotic pain medicine, sleeping
pills, muscle relaxers, and medicine for seizures, depression or
anxiety can add to sleepiness caused by mephobarbital. Tell your
doctor if you need to use any of these other medicines while you
are taking mephobarbital.
Tell your doctor about all other medications you use,
especially:
a blood thinner such as warfarin (Coumadin);
doxycycline (Adoxa, Doryx, Oracea, Vibramycin);
griseofulvin (Grisactin, Fulvicin PG, Grifulvin V);
phenobarbital (Solfoton);
steroid medicines such as
hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone,
Deltasone), and others;
phenytoin (Dilantin), divalproex sodium (Depakote), valproic
acid (Depakene); or
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil),
rasagiline (Azilect), selegiline (Eldepryl, Emsam), or
tranylcypromine (Parnate).
This list is not complete and there may be other drugs that can
interact with mephobarbital. Tell your doctor about all your
prescription and over-the-counter medications, vitamins,
minerals, herbal products, and drugs prescribed by other
doctors. Do not start a new medication without telling your
doctor.
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