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 Ephedrine stimulates lipolysis by increasing noradrenaline
(NA) release from sympathetic nerve terminals. This increase in
noradrenaline activates adrenergic receptors which increases cAMP
levels in fat cells and muscle cells. This has the effect of
increasing lipolysis in fat cells and increasing protein synthesis
in muscle tissue. Negative feedback mechanisms are activated as
well, and involve the production of phosphodiesterases, adenosine,
and prostaglandins. Caffeine has the ability to inhibit
phosphodiesterase activity and interfere with the adenosine
receptor. This combined with its ability to prevent some NA
re-uptake12 increase the effectiveness of ephedrine in a
synergistic fashion. Aspirin has been shown to increase the
effectiveness of ephedrine in some individuals presumably by its
actions as a prostaglandin inhibitor.
Maximum effectiveness is achieved when taking 20 mg ephedrine with
200 mg caffeine and 300 mg aspirin three times a day about one
half hour before meals. Common side effects are associated with
its sympathetic activity namely, anorexia, initial rise in blood
pressure, initial tachycardia, slowed GI motility (constipation),
insomnia, agitation, anxiety, nervousness and depression- like
withdrawal symptoms. Most all of these symptoms exhibit tachyphylaxis after about 4-6 weeks. Thermogenic activity seems to
last upwards of 20 weeks due to its low desensitization properties
and beta-3 affinity. About 75% of ephedrine’s effects on weight
loss in the obese are due to appetite control.
PHEDRAX Plus® Product
Description
Discover PHEDRAX Plus® – the fast-acting, effective, temporary
asthma treatment – without a prescription. PHEDRAX Plus® tablets
are the hottest-selling PHEDRAXrine asthma treatment product on
the market today, helping people breathe easier. With Taj
Pharmaceuticals’ proven dual-acting formula – a combination of a
bronchodilator and expectorant – our PHEDRAX Plus® provides
temporary relief of mild intermittent asthma symptoms including:
• shortness of breath
• tightness of chest
• wheezing
• excessive phlegm (mucus)
PHEDRAX Plus® thins bronchial secretions to rid bronchial
passageways of bothersome mucus and makes coughs more
productive.
PHEDRAX Plus® tablets are offered in two formulas dependent on
state regulations: 25 mg PHEDRAXrine HCl and 200 mg guaifenesin,
and 12.5 mg PHEDRAXrine HCl.
* For 25 mg PHEDRAXrine, there is a purchase limit of 3 boxes
per day.
* For 25 mg PHEDRAXrine, there is a purchase limit of 3 boxes
per month.
* For 12.5 mg PHEDRAXrine, there is a purchase limit of 6 boxes
per day.
* For 12.5 mg PHEDRAXrine, there is a purchase limit of 6 boxes
per month.
* PHEDRAXrine and pseudoPHEDRAXrine products may not be ordered
at the same time.
Anyone considering taking ephedrine, caffeine and aspirin should
educated themselves first about the potential side effects.
Individuals with pre-existing high blood pressure should not use
sympathomimetics such as ephedrine. When taking herbal forms of
ephedrine, be sure you understand just how much is in each
serving. Be aware that herbal preparations are standardized but
you still can not be sure exactly how much you are taking with
each capsule.
GENERAL DESCRIPTION & APPLICATIONS
Ephedrine is a sympathomimetic alkaloid originally obtained from
species of Ephedra or prepared synthetically. Its action is
similar to that of epinephrine (a catecholamine hormone secreted
by the adrenal medulla and a neurotransmitter). Its effects,
although less powerful, are more prolonged, and it exerts action
when administered orally, whereas epinephrine is effective only by
injection. It is used as muscle relaxants, central nervous system
and cardiac muscle stimulants in combination with others like
theophylline. It is used to prevent hypotension during spinal and
infiltration anesthesia; and as a mydriatic. There are enantiomers
in ephedrine structure. (1R,2S)- and (1S,2R)-enantiomers are
designated ephedrine (opposite stereoisomerisms around the chiral
center), whereas (1R,2R)- and (1S,2S)-enantiomers are designated
pseudoephedrine. Commercial ephedrine is (-)-(1R,2S)-ephedrine
[also called (-)-Ephedrine or L-ephedrine], while commercial
pseudoephedrine enantiomer is (1S,2S)-pseudoephedrine [(+)-pseudoephedrine
or D-pseudoephedrine]. Pseudoephedrine has less pressor action and
fewer central stimulant effects than ephedrine. Pseudoephedrine is
used as a nasal decongestant and a bronchodilator to relaxe and
open the air passages to the lung to increase the flow of air, and
thus is used in the treatment and/or prevention of symptoms of
bronchial asthma and of reversible bronchospasm associated with
chronic bronchitis and emphysema.
Ephedrine stimulates lipolysis by increasing noradrenaline
(NA) release from sympathetic nerve terminals. This increase in
noradrenaline activates adrenergic receptors which increases cAMP
levels in fat cells and muscle cells. This has the effect of
increasing lipolysis in fat cells and increasing protein synthesis
in muscle tissue. Negative feedback mechanisms are activated as
well, and involve the production of phosphodiesterases, adenosine,
and prostaglandins. Caffeine has the ability to inhibit
phosphodiesterase activity and interfere with the adenosine
receptor. This combined with its ability to prevent some NA
re-uptake12 increase the effectiveness of ephedrine in a
synergistic fashion. Aspirin has been shown to increase the
effectiveness of ephedrine in some individuals presumably by its
actions as a prostaglandin inhibitor.
Maximum effectiveness is achieved when taking 20 mg ephedrine with
200 mg caffeine and 300 mg aspirin three times a day about one
half hour before meals. Common side effects are associated with
its sympathetic activity namely, anorexia, initial rise in blood
pressure, initial tachycardia, slowed GI motility (constipation),
insomnia, agitation, anxiety, nervousness and depression- like
withdrawal symptoms. Most all of these symptoms exhibit
tachyphylaxis after about 4-6 weeks. Thermogenic activity seems to
last upwards of 20 weeks due to its low desensitization properties
and beta-3 affinity. About 75% of ephedrine’s effects on weight
loss in the obese are due to appetite control.
Anyone considering taking ephedrine, caffeine and aspirin should
educated themselves first about the potential side effects.
Individuals with pre-existing high blood pressure should not use
sympathomimetics such as ephedrine. When taking herbal forms of
ephedrine, be sure you understand just how much is in each
serving. Be aware that herbal preparations are standardized but
you still can not be sure exactly how much you are taking with
each capsule.
Presentation
Phedrax Tablets
Strip of 20 Tablets
PHEDRAXrine HCl and 200 mg guaifenesin, and 12.5 mg
* For 25 mg PHEDRAXrine, there is a purchase limit of 3 boxes
per day.
* For 25 mg PHEDRAXrine, there is a purchase limit of 3 boxes
per month.
* For 12.5 mg PHEDRAXrine, there is a purchase limit of 6 boxes
per day.
* For 12.5 mg PHEDRAXrine, there is a purchase limit of 6 boxes
per month.
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Note : This product information is intended only
for residents of the India. Taj Pharmaceuticals Limited,
medicines help to treat and prevent a range of conditions—from the
most common to the most challenging—for people around the world.
Information for Health Care Professionals
This title may be cited as the "Controlled Substances Import and Export
Act.'' EXPORT IS SUBJECTED TO NOC (Narcotic Drugs Import and Export Act)
INDIA.
Export/ Import
ANY NARCOTIC DRUGS OR PSYCHOTROPIC SUBSTANCES CAN BE IMPORTED INTO/
EXPORTED OUT OF INDIA SUBJECT TO RULE 53 AND RULE 53-A OF THE NDPS
RULES, 1985.
The import of - (i) opium, concentrate of poppy straw, and (ii)
morphine, codeine, thebaine, and their salts is prohibited save by the
Government Opium Factory under the provision of Rule 54 of the NDPS
Rules, 1985. The import into and export out of India of any narcotic
drugs or psychotropic substances specified in Schedule I is prohibited
under the provision of Rule 53 of the NDPS Rules, 1985. The export of
any narcotic drugs or psychotropic substances or preparations containing
any of such narcotic drugs or psychotropic substances specified in
Schedule II shall be prohibited to the countries or to the region of
such country specified therein under the provision of Rule 53-A of the
NDPS Rules, 1985.The manufacture of psychotropic substances specified in
Schedule III can be allowed for export purpose only under the provision
of Rule 65(1) of the NDPS Rules, 1985. The import of psychotropic
substances specified in Schedule III may be allowed for test/ analysis
purpose as well as for re-export purpose. The export out of / import
into India of a select number of Precursor Chemicals is exercised by
the Narcotics Commissioner in accordance with Directorate General of
Foreign Trade (DGFT) notification and Administrative Control.
ANY COMPANY/APPLICANT DESIROUS OF OBTAINING NO OBJECTION CERTIFICATE FOR
EXPORT OF NOTIFIED PRECURSOR CHEMICALS ARE REQUIRED TO APPLY TO THE
NARCOTICS COMMISSIONER. (UNDER RULES FROM CENTRAL BUREAU OF NARCOTICS,
GOVERNMENT OF INDIA)
*** Please consult local Prescribing
Information for any product before use. This website is an
international information resource for healthcare professionals
with an interest in disease management. This website is not
intended to replace the advice of a qualified healthcare
professional. Above brand is a trademark of the Taj group of
companies (Taj Pharmaceuticals Limited). |
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Quality
