This preparation is designed solely for parenteral use only after
addition of drugs that require dilution or must be dissolved in an
aqueous vehicle prior to injection.
Water for Injection is a sterile, nonpyrogenic preparation of
water for injection that does not contain any chemical and
biological admixtires or added buffers and is supplied only in
single-dose containers to dilute or dissolve drugs for injection.
Water is an essential constituent of all body tissues and accounts
for approximately 70% of total body weight. Average normal adult
daily requirement ranges from two to three liters (1.0 to 1.5
liters each for insensible water loss by perspiration and urine
Water balance is maintained by various regulatory mechanisms.
Water for distribution depends primarily on the concentration of
electrolytes in the body compartments and sodium (Na+) plays a
major role in maintaining physiologic equilibrium.
The small volume of fluid provided by Sterile Water for Injection,
USP when used only as a pharmaceutic aid for diluting or
dissolving drugs for parenteral injection, is unlikely to exert a
significant effect on fluid balance except possibly in neonates or
very small infants.
This parenteral preparation is indicated only for diluting or
dissolving drugs for intravenous, intramuscular or subcutaneous
injection, according to instructions of the manufacturer of the
drug to be administered.
Contraindications and cautions:
Sterile Water for Injection must be made approximately isotonic
prior to use.
Intravenous administration of sterile water for Injection without
a solute may result in hemolysis.
Do not use for intravenous injection unless the osmolar
concentration of additives results in an approximate isotonic
Consult the manufacturer's instructions for choice of vehicle,
appropriate dilution or volume for dissolving the drugs to be
injected, including the route and rate of injection.
Inspect reconstituted (diluted or dissolved) drugs for clarity (if
soluble) and freedom from unexpected precipitation or
discoloration prior to administration.
Use water for injections only as a diluent or solvent. This
parenteral preparation is unlikely to pose a threat of fluid
overload except possibly in neonates or very small infants. In the
event these should occur, re-evaluate the patient and institute
appropriate corrective measures.
Adverse effects: There are possible side-effects associated with
this medicine that can affect individuals in different ways. If a
side effect is stated here, that does not necessarily mean the
fact that all people using water for injections will experience it
or any other.
Reactions which may occur because of this solution, added drugs or
the technique of reconstitution or administration include febrile
response, local tenderness, abscess, tissue necrosis or infection
at the site of injection, venous thrombosis or phlebitis extending
from the site of injection and extravasation.
If an adverse reaction does occur, discontinue the infusion,
evaluate the patient, institute appropriate countermeasures, and
if possible, retrieve and save the remainder of the unused vehicle
The side effects listed above may not include all of the side
effects reported by the drug's manufacturer. For more information
about any other possible risks associated with water for
injections, please read the information provided with water for
injections or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines
you are already taking, including those bought without a
prescription and herbal medicines, before you start treatment with
water for injections. Similarly, check with your doctor or
pharmacist before taking any new medication while taking this one,
to ensure that the combination is safe.
Do not mix water for injections with oil solutions for
intramuscular or intravenous application.
Additional Information :
DO NOT SHARE water for injections with others. DO NOT USE THIS
MEDICINE for other health conditions. KEEP THIS PRODUCT, as well
as syringes and needles, if needed during treatment, out of the
reach of children. Do not reuse needles, syringes, or other